1) The first successful human heart transplant was performed by Dr. Christiaan Barnard in 1967.

2) The oldest known musical instrument is a flute made from a bird bone, estimated to be around 43,000 years old.

3) Johnny Depp is an American actor and producer known for his unique and versatile performances in films such as the "Pirates of the Caribbean" series, "Edward Scissorhands," and "Sweeney Todd: The Demon Barber of Fleet Street." He has received multiple accolades for his work.

4) The highest-grossing film of all time is "Avengers: Endgame," which has earned over $2.79 billion at the global box office.